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Mar 8, 2024 · Beta-lactamases are enzymes that open the beta-lactam ring, inactivating the antibiotic. The first plasmid-mediated beta-lactamase in gram-negative bacteria was discovered in Greece in the 1960s. It was named TEM after the patient from whom it was isolated (Temoniera) [ 2 ]. Subsequently, a closely related enzyme was discovered and named TEM-2. UpToDate is an online clinical resource tool for physicians and patients that provides information on various specialties and topics. Click on one of the specialties to see …Licensed to: UpToDate Marketing Professional Support Tag : [1102 - 40.77.189.15 - 7D44A5896D - PR14 - UPT - 20240511-08:06:01UTC] - SM - MD - LG - XL LoadingThis topic will focus on the treatment of hypernatremia induced by water loss, which is the most common cause. The treatment of hypernatremia in patients with impaired thirst, with or without arginine vasopressin disorders, and with primary sodium overload will also be reviewed. The causes and evaluation of patients with hypernatremia and the ...

For over 30 years, clinicians around the world have trusted the evidence-based content in the UpToDate® clinical decision support (CDS) system to help make crucial care decisions when it matters most. Founded by clinicians for clinicians, and backed by an expert editorial team in over 25 specialties, UpToDate provides the latest medical ... Gastroesophageal reflux disease (GERD) is notable for its high prevalence, variety of clinical presentations, under-recognized morbidity, and substantial economic consequences. This topic will review the clinical manifestations and diagnosis of GERD. The pathophysiology and management of GERD are discussed in detail separately.

PARENTERAL DRUGS. A variety of parenteral and oral antihypertensive drugs are available for use in these patients ( table 1) [ 1-7 ]. Few studies have compared these agents with one another, and all are tolerated reasonably well [ 8,9 ]. Thus, the drug of choice is often dictated by the type of hypertensive emergency and the local hospital ...

Immune thrombocytopenia (ITP, also called idiopathic thrombocytopenic purpura, immune thrombocytopenic purpura) is an acquired thrombocytopenia caused by autoantibodies against platelet antigens. It is one of the more common causes of thrombocytopenia in otherwise asymptomatic adults. Major diagnostic concerns in an …Evidence-based medicine (EBM) is the care of patients using the best available research evidence to guide clinical decision-making ( figure 1) [ 1,2 ]. The value of EBM is heightened in light of the following considerations: The volume of evidence available to guide clinical decisions continues to grow at a rapid pace ( figure 2)Acute pancreatitis should be suspected in patients with severe acute upper abdominal pain but requires biochemical or radiologic evidence to establish the diagnosis. This topic will review the clinical manifestations and diagnosis of acute pancreatitis. The etiology, pathogenesis, assessment of severity, and management of acute pancreatitis are ...Group A Streptococcus (GAS), or Streptococcus pyogenes, is the leading bacterial cause of tonsillopharyngitis in adults and children worldwide. GAS is one of the few causes of tonsillopharyngitis or pharyngitis for which antibiotic treatment is recommended. The treatment and prevention of group A streptococcal tonsillopharyngitis is reviewed here.Potassium enters the body via oral intake or intravenous infusion, is largely stored in the cells, and is then excreted in the urine. The major causes of hyperkalemia are increased potassium release from the cells and, most often, reduced urinary potassium excretion ( table 1 ). This topic will review the causes and evaluation of hyperkalemia.

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Disclaimer: This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options.

You receive the entire UpToDate library of specialties with your subscription. Click on a section below to view a detailed list of topics associated with that particular section. If you'd like to see the table of contents for other specialties, click here. Practice Changing UpDates. What's New. Patient Education. Calculators. Authors and Editors. Licensed to: UpToDate Marketing Professional Support Tag : [1102 - 104.224.14.69 - 24B2D16B6F - PR14 - UPT - 20240430-16:47:09UTC] - SM - MD - LG - XL LoadingUpToDate® registrants and Individual subscribers can now answer their clinical questions anytime, anywhere by downloading this app onto an Android™ phone …Display complete list of interactions for an individual item by clicking item name. Add another item to analyze for potential interactions. NOTE: This tool does not address chemical compatibility related to I.V. drug preparation or administration. View interaction detail by clicking on link (s) below.Conjunctivitis, also called "pink eye," is defined as an inflammation of the conjunctiva. The conjunctiva is the thin membrane that lines the inner surface of the eyelids and the whites of the eyes (called the sclera) ( figure 1 ). Conjunctivitis can affect children and adults. The most common symptoms of conjunctivitis include a red eye and ...

Other manifestations include lower abdominal pain and cramping, low-grade fever, nausea, and anorexia [ 2,5 ]. Diarrhea may be associated with mucus or occult blood, but melena or hematochezia are rare. Fever is associated with CDI in about 15 percent of cases; temperature >38.5°C may occur in the setting of nonsevere or severe CDI.Google today introduced a new mobile management and security solution, Android Enterprise Essentials, which, despite its name, is actually aimed at small to medium-sized businesses...Gastroesophageal reflux disease (GERD) is notable for its high prevalence, variety of clinical presentations, under-recognized morbidity, and substantial economic consequences. This topic will review the clinical manifestations and diagnosis of GERD. The pathophysiology and management of GERD are discussed in detail separately.UpToDate is a trusted source of clinical information for health professionals. However, the page you are looking for can't be found. Try searching for a different topic or language.EVALUATION AND DIAGNOSIS. The history and physical examination in patients presenting with a severely elevated blood pressure (or an acute rise in blood pressure over a previously normal baseline, even if the presenting pressure is <180/120 mmHg) should determine whether any of the following are present [ 1,5 ]: Acute head …Bushmills, in Northern Ireland, is known for the famous whiskey distillery of the same name in the town. But there's more to it than that. In Northern Ireland nothing says cozy lik...

INTRODUCTION. —. Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide. The clinical presentation of CAP varies, ranging from mild pneumonia characterized by fever and productive cough to severe pneumonia characterized by respiratory distress and sepsis.

This topic will focus on the treatment of hypernatremia induced by water loss, which is the most common cause. The treatment of hypernatremia in patients with impaired thirst, with or without arginine vasopressin disorders, and with primary sodium overload will also be reviewed. The causes and evaluation of patients with hypernatremia and the ...Oral options include penicillin V potassium, amoxicillin, cephalexin, and cefadroxil. Parenteral options include cefazolin, nafcillin, and flucloxacillin. (See 'Treatment of erysipelas' above.) Duration of antibiotic therapy – We suggest five to six days of therapy rather than longer durations ( Grade 2C ).Angioedema is self-limited, localized subcutaneous (or submucosal) swelling, which results from extravasation of fluid into interstitial tissues. Angioedema may occur in isolation, accompanied by urticaria, or as a component of anaphylaxis. The clinical features, diagnosis, differential diagnosis, and management of angioedema will be …UpToDate. With powerful and practical knowledge at your fingertips, UpToDate® is the only clinical decision support resource associated with improved patient outcomes. Purchase …Contents. You have access to the entire UpToDate® library of specialties with your subscription. Click on one of the specialties below to see sections associated with each. You can also view Practice Changing UpDates, What’s New, Patient Education, Authors and Editors, Calculators, and Drug Information. Practice Changing UpDates.Sign in with Microsoft. Sign in with Open Athens. Sign in Another Way. If your organization permits Single Sign-On (SSO) for UpToDate, you may use your email address here. If …Acute pancreatitis refers to inflammation of the pancreas, causing sudden and severe abdominal pain. The pancreas is an organ that lies in the back of the mid-abdomen ( figure 1 ). It produces digestive juices and certain hormones, including insulin. Pancreatitis usually develops as a result of gallstones or moderate to heavy alcohol ...Polycystic ovary syndrome (PCOS) is a condition that causes irregular menstrual periods, symptoms of excess androgens (acne, hirsutism, and scalp hair loss), and ovaries that appear "polycystic" on pelvic ultrasound. The condition occurs in approximately 5 to 10 percent of females. Many females with PCOS are overweight or …Allergic conjunctivitis is caused by airborne allergens contacting the eye, which leads to immunoglobulin E (IgE) mediated local mast cell degranulation and allergic inflammation. It typically presents as bilateral ocular itching, redness, and watery discharge. This topic discusses the management of allergic conjunctivitis. UpToDate is an online resource that helps you make informed decisions about medical care. Access the latest evidence, expert opinions, and patient education with your subscription.

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Jun 10, 2022 · INTRODUCTION. —. Tetanus is a nervous system disorder characterized by muscle spasms that is caused by the toxin-producing anaerobe Clostridium tetani, which is found in the soil. The clinical features of tetanus and its relationship to traumatic injuries were well known among the ancient Greeks and Egyptians and to many clinicians before the ...

Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterized by fluctuating motor weakness involving ocular, bulbar, limb, and/or respiratory muscles. The weakness is due to an antibody-mediated, immunologic attack directed at proteins in the postsynaptic membrane of the neuromuscular junction (acetylcholine receptors or ...Medicine Matters Sharing successes, challenges and daily happenings in the Department of Medicine Dr. Mary Catherine Beach, professor in the Division of General Internal Medicine, ... UpToDate offers a number of subscriptions and add-on products, allowing you to have the most up-to-date information and improve patient care. The azoles that are available for systemic use can be classified into two groups: the triazoles (fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole) and the imidazoles (ketoconazole). An overview of the use of azole agents for the treatment of various systemic fungal infections will be reviewed here.Beta-lactamases are enzymes that open the beta-lactam ring, inactivating the antibiotic. The first plasmid-mediated beta-lactamase in gram-negative bacteria was discovered in Greece in the 1960s. It was named TEM after the patient from whom it was isolated (Temoniera) [ 2 ]. Subsequently, a closely related enzyme was discovered and named TEM-2.Powerful and practical clinical knowledge at your fingertips, a personal subscription to UpToDate provides consistent, convenient access to enhance your daily medical practice. UpToDate helps you stay current on the latest evidence-based recommendations across 25 specialties to find answers to your clinical questions. Subscribe.UpToDate is a trusted online resource for clinicians worldwide, providing up-to-date information and improving patient care. Choose your country, role and profession to …Oral options include penicillin V potassium, amoxicillin, cephalexin, and cefadroxil. Parenteral options include cefazolin, nafcillin, and flucloxacillin. (See 'Treatment of erysipelas' above.) Duration of antibiotic therapy – We suggest five to six days of therapy rather than longer durations ( Grade 2C ).This topic will focus on the treatment of hypernatremia induced by water loss, which is the most common cause. The treatment of hypernatremia in patients with impaired thirst, with or without arginine vasopressin disorders, and with primary sodium overload will also be reviewed. The causes and evaluation of patients with hypernatremia and the ...

The spectrum of activity and pharmacology of combination beta-lactamase inhibitors, carbapenems, and monobactams will be reviewed here. The mechanisms of action and resistance and major adverse reactions of the beta-lactam antibiotics, issues related to penicillins, and cephalosporins are discussed separately.May 4, 2023 · The pharmacology, efficacy, contraindications, and side effects of metformin for the treatment of diabetes will be reviewed here. A general discussion of initial treatment of type 2 diabetes and the role of metformin in the prevention of diabetes, in the treatment of polycystic ovary syndrome, and in gestational diabetes are reviewed separately. UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Obstetrics, Gynecology, and Women ...The signs and symptoms of anemia include paleness, weakness, and fatigue. Impaired kidney function — The excess proteins and high blood calcium levels associated with MM can damage the kidneys. Kidney function is abnormal at diagnosis in about half of individuals with multiple myeloma.Instagram:https://instagram. fidget spinner Feb 12, 2024 · Although hypokalemia can be transiently induced by the entry of potassium into the cells, most cases result from unreplenished gastrointestinal or urinary losses due, for example, to vomiting, diarrhea, or diuretic therapy [ 1-3 ]. (See "Causes of hypokalemia in adults" .) Potassium replacement is primarily indicated when hypokalemia is due to ... Nausea, the unpleasant sensation of being about to vomit, can occur alone or can accompany vomiting (the forceful expulsion of gastric contents), dyspepsia, or other gastrointestinal symptoms. Nausea can occur without vomiting and, less commonly, vomiting occurs without nausea. Nausea is often more bothersome and disabling than … how do i find a song Trusted expert editorial content. The heart of UpToDate is over 7,400 expert clinicians, editors, and reviewers who review and assemble the latest evidence-based clinical, … fresno to vegas flights Blood pressure is reported as the systolic pressure over diastolic pressure (eg, 120/70 or "120 over 70"). Untreated high blood pressure increases the strain on the heart and arteries, eventually causing organ damage. High blood pressure increases the risk of heart failure, heart attack (myocardial infarction), stroke, and kidney failure.UpToDate provides clinical and drug information, patient education, and AI-powered technologies to support better patient care. Learn about the UpToDate suite of solutions, research, integrations, experts, and CME resources. brewers bay beach Other manifestations include lower abdominal pain and cramping, low-grade fever, nausea, and anorexia [ 2,5 ]. Diarrhea may be associated with mucus or occult blood, but melena or hematochezia are rare. Fever is associated with CDI in about 15 percent of cases; temperature >38.5°C may occur in the setting of nonsevere or severe CDI. skype web page Justin Bufkin of One Smile Closer shares how he started a photography business on the side. He shares tips on anyone can make money with photography. Part-Time Money® Make extra mo... plane ticket to seattle Evidence-based medicine (EBM) is the care of patients using the best available research evidence to guide clinical decision-making ( figure 1) [ 1,2 ]. The value of EBM is heightened in light of the following considerations: The volume of evidence available to guide clinical decisions continues to grow at a rapid pace ( figure 2) aliexpress espana PARENTERAL DRUGS. A variety of parenteral and oral antihypertensive drugs are available for use in these patients ( table 1) [ 1-7 ]. Few studies have compared these agents with one another, and all are tolerated reasonably well [ 8,9 ]. Thus, the drug of choice is often dictated by the type of hypertensive emergency and the local hospital ...UpToDate, the evidence-based clinical decision support resource from Wolters Kluwer, is trusted at the point of care by clinicians worldwide. For the best experience, we recommend using the most recent versions of Microsoft Edge, Mozilla® Firefox®, and Google Chrome™. joe v's store UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, … eat the frog book Dec 11, 2023 · Patient level information — UpToDate offers two types of patient education materials. The Basics — The Basics patient education pieces answer the four or five key questions a patient might have about a given condition. These articles are best for patients who want a general overview and who prefer short, easy-to-read materials. minecraft pocket edition pocket If your organization permits Single Sign-On (SSO) for UpToDate, you may use your email address here. If not, please enter your Username. Close Subscribe. Subscribe. UpToDate offers a number of subscriptions and add-on products, allowing you to have the most up-to-date information and improve patient care. About Us ... pandora channels Intravenous thrombolysis can be administered up to 4.5 hours after symptom onset, and mechanical thrombectomy can be administered up to 24 hours after symptom onset. (See "Approach to reperfusion therapy for acute ischemic stroke" and "Intravenous thrombolytic therapy for acute ischemic stroke: Therapeutic use" and "Mechanical …UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Obstetrics, Gynecology, and Women ...